The conference is jointly organised by INFN-Sezione di Genova and the Department of Physics of the University of Genova. It aims at gathering an overview of the status and future prospects of astrophysics and cosmology with a multi-messenger approach. The conference will feature only plenary sessions that will deal with astrophysics with electromagnetic waves, astrophysics with gravitational waves, astroparticle physics and neutrino astrophysics, nuclear astrophysics, cosmology. The sessions and the talks will be organised according to astrophysical sources and phenomena: compact objects, neutron star mergers, supernovae, active galactic nuclei, CMB, ..... highlighting the current status of the knowledge and the benefit of a multi-messenger approach.